Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00441)
MIC Name Coprococcus catus (firmicutes)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Coprococcus
Species: Coprococcus catus
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Positive
Genome Size (bp) 3522704
Description Coprococcus catus is a species of obligately anaerobic, Gram positive bacterium. The population of Coprococcus catus, a bacterium notable for production of large quantities of short chain (propionic and butyric) fatty acids, which in turn may provide protection against colon cancer.
External Links Taxonomy ID
116085
Genome Assembly ID
ASM21055v1
GOLD Organism ID
Go0004337
Disease Relevance
          Autoimmune liver disease  [ICD-11: DB96]
             Description Coprococcus catus was decreased in patients with primary sclerosing cholangitis. [1]
          Colon cancer  [ICD-11: 2B90]
             Description Coprococcus catus may provide protection against colon cancer. [2]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Coprococcus catus and Ruminococcus gnavus were decreased in inflammatory bowel disease. [1]
          Ulcerative colitis  [ICD-11: DD71]
             Description Coprococcus catus was decreased in ulcerative colitis patients. [1]
Host Genetic Factors (HGFs)
          NOD2
             HGF ID HGF2335 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of NOD2 showed significantly increased abundance of Coprococcus catus (p-value<0.05). [3]
          rs2075820
             HGF ID HGF1458 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The variant gene NOD1 of innate immunity rs2075820 is significantly associated with the abundance of gut micriobiota Coprococcus catus (p-value=0.0467). [4]
Environmental Factor(s)
             Disbiome ID
      390
             gutMDisorder ID
      gm0223
References
1 Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis. World J Gastroenterol. 2017 Jul 7;23(25):4548-4558. doi: 10.3748/wjg.v23.i25.4548.
2 Effects of ingested nanocellulose on intestinal microbiota and homeostasis in Wistar Han rats. NanoImpact. 2020 Apr;18:100216. doi: 10.1016/j.impact.2020.100216. Epub 2020 Feb 28.
3 Nod2 and Nod2-regulated microbiota protect BALB/c mice from diet-induced obesity and metabolic dysfunction.Sci Rep. 2017 Apr 3;7(1):548. doi: 10.1038/s41598-017-00484-2.
4 Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.

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