Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00572)
MIC Name Holdemanella biformis (firmicutes)
MIC Synonyms Bacteroides biformis
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Erysipelotrichia
Order: Erysipelotrichales
Family: Erysipelotrichaceae
Genus: Holdemanella
Species: Holdemanella biformis
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Positive
Host Relationship Commensal
Genome Size (bp) 2415920
Description Holdemanella biformis is an obligately anaerobic, Gram positive bacterium.
External Links Taxonomy ID
1735
Genome Assembly ID
ASM15665v1
GOLD Organism ID
Go0477219
Disease Relevance
          Cystic fibrosis  [ICD-11: CA25]
             Description Eubacterium biforme was abundant in severe Cystic fibrosis patients. [1]
          Parkinsonism  [ICD-11: 8A00]
             Description Eubacterium biforme was markedly lowered in Parkinsons disease samples. [2]
Host Genetic Factors (HGFs)
          C4B
             HGF ID HGF2348 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description The low C4B-CN has been significantly associated with the high abundance of Eubacterium biforme (p-value<0.05). [3]
          rs3134798
             HGF ID HGF1453 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs3134798 SNP is significantly associated with the abundance of Eubacterium biforme (p-value=5.76E-04). [4]
Environmental Factor(s)
             Disbiome ID
      392
             gutMDisorder ID
      gm0310
References
1 Cystic fibrosis transmembrane conductance regulator (CFTR) allelic variants relate to shifts in faecal microbiota of cystic fibrosis patients. PLoS One. 2013 Apr 17;8(4):e61176. doi: 10.1371/journal.pone.0061176. Print 2013.
2 Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-nave Parkinson's disease patients. Genome Med. 2017 Apr 28;9(1):39. doi: 10.1186/s13073-017-0428-y.
3 C4B gene influences intestinal microbiota through complement activation in patients with paediatric-onset inflammatory bowel disease.Clin Exp Immunol. 2017 Dec;190(3):394-405. doi: 10.1111/cei.13040. Epub 2017 Sep 25.
4 Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD.Gut. 2020 Jul 10:gutjnl-2019-319706. doi: 10.1136/gutjnl-2019-319706. Online ahead of print.

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