| General Information of MIC (ID: MIC00688) |
| MIC Name |
Klebsiella sp. (enterobacteria)
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| Body Site |
Gut
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| Lineage |
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Klebsiella
Species: Klebsiella sp.
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| Oxygen Sensitivity |
Strictly anaerobe
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| Microbial Metabolism |
Fermentative
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| Gram |
Negative
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| Host Relationship |
Opportunistic pathogen
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| Description |
Klebsiella is a genus of Gram-negative, oxidase-negative, rod-shaped bacteria with a prominent polysaccharide-based capsule.
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| External Links |
Taxonomy ID |
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| GOLD Organism ID |
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| Disease Relevance |
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| Inflammatory bowel disease [ICD-11: DD72] |
| Description |
Klebsiella spp. appeared to be strongly associated with irritable bowel disease. |
[1] |
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| Host Genetic Factors (HGFs) |
| C4B |
| HGF ID |
HGF2348 |
HGF Info
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Class |
Copy Number Variation: Gene Duplication (CNV-GDu) |
| Description |
The low C4B-CN has been significantly associated with the decreased abundance of Klebsiella (p-value<0.05). |
[2] |
| hsa-miR-106a-5p |
| HGF ID |
HGF0288 |
HGF Info
|
Class |
Non-coding RNA: Micro (ncRNA-miRNA) |
| Description |
The regulation of miR-106a was significantly associated with the abundance of Klebsiella (p-value<0.05). |
[3] |
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| Environmental Factor(s) |
| Disbiome ID |
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| gutMDisorder ID |
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| References |
| 1 |
Learning representations of microbe-metabolite interactions. Nat Methods. 2019 Dec;16(12):1306-1314. doi: 10.1038/s41592-019-0616-3. Epub 2019 Nov 4.
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| 2 |
C4B gene influences intestinal microbiota through complement activation in patients with paediatric-onset inflammatory bowel disease.Clin Exp Immunol. 2017 Dec;190(3):394-405. doi: 10.1111/cei.13040. Epub 2017 Sep 25.
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| 3 |
MiR-1178 regulates mycobacterial survival and inflammatory responses in Mycobacterium tuberculosis-infected macrophages partly via TLR4. Shi G, Mao G, Xie K, Wu D, Wang W.. J Cell Biochem. 2018 Sep;119(9):7449-7457. doi: 10.1002/jcb.27054. Epub 2018 May 21.
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