Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01033)
MIC Name Propionibacterium freudenreichii (actinobacteria)
MIC Synonyms Propionicibacterium freudenreichii
Body Site Skin
Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Propionibacteriales
Family: Propionibacteriaceae
Genus: Propionibacterium
Species: Propionibacterium freudenreichii
Oxygen Sensitivity Aerotolerant
Microbial Metabolism Saccharolytic; Fermentative
Gram Positive
Host Relationship Probiotic
Genome Size (bp) 2614705
No. of Coding Genes 2330
No. of Non-Coding Genes 49
No. of Small Non-Coding Genes 49
No. of Gene Transcripts 2397
No. of Pseudogenes 18
No. of Base Pairs 2614705
Description Propionibacterium freudenreichii is an aerotolerant, Gram-positive, non-motile bacterium. Propionibacterium freudenreichii can alleviate symptoms and enhance treatment of ulcerative colitis in clinical trials.
External Links Taxonomy ID
1744
Genome Assembly ID
CIRM-BIA122
GOLD Organism ID
Go0001786
Disease Relevance
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Propionibacterium freudenreichii was associated with inflammatory bowel disease. [1]
Host Immune Factors (HIFs)
          Macrophages
             HIF ID HIFC0020 HIF Info       Class Macrophages (Mac)
             Description Attenuation of colitis by DHNA from Propionibacterium freudenreichii may partly be a result of its direct action on intestinal macrophages to inhibit proinflammatory cytokine production. [2]
Environmental Factor(s)
             Disbiome ID
      101
             gutMDisorder ID
      gm0543
References
1 Combining selected immunomodulatory Propionibacterium freudenreichii and Lactobacillus delbrueckii strains: Reverse engineering development of an anti-inflammatory cheese. Mol Nutr Food Res. 2016 Apr;60(4):935-48. doi: 10.1002/mnfr.201500580. Epub 2015 Dec 29.
2 1,4-Dihydroxy-2-naphthoic acid from Propionibacterium freudenreichii reduces inflammation in interleukin-10-deficient mice with colitis by suppressing macrophage-derived proinflammatory cytokines. J Leukoc Biol. 2013 Sep;94(3):473-80. doi: 10.1189/jlb.0212104. Epub 2013 Jun 25.

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