General Information of MIC (ID: MIC01142)
MIC Name	Ruminococcus torques (firmicutes)
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Lachnospiraceae Genus: Mediterraneibacter Species: Ruminococcus torques
Oxygen Sensitivity	Obligate anaerobe
Microbial Metabolism	Saccharolytic; Fermentative
Gram	Positive
Host Relationship	Commensal
Genome Size (bp)	2739406
Description	Ruminococcus torques is an obligately anaerobic, Gram positive, non-motile and non-spore forming bacterium. Ruminococcus torques was associated with severity of bowel symptoms.
External Links	Taxonomy ID	33039
	Genome Assembly ID	ASM15392v1
	GOLD Organism ID	Go0000919
Disease Relevance
Amyotrophic lateral sclerosis  [ICD-11: 8B60]
Description	Ruminococcus torques exacerbated the symptoms of amyotrophic lateral sclerosis.				[1]
Crohn disease  [ICD-11: DD70]
Description	The abundance of Ruminococcus torques was low in C-reactive protein (CRP)-positive CD(Crohns disease) patients.				[2]
Irritable bowel syndrome  [ICD-11: DD91]
Description	Certain bacterial phylotypes might serve as markers of symptom severity in IBS(Irritable bowel syndrome). While the presence of Ruminococcus torques 94% was associated with an increase in symptom severity, some other phylotypes seemed to act in the opposite direction.				[3]

Host Genetic Factors (HGFs)
SMARCAD1
HGF ID	HGF2342	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of SMARCAD1 was significantly associated with a decrease of Ruminococcus torgues (p-value<0.05).				[4]

Environmental Factor(s)
Disbiome ID			137
gutMDisorder ID			gm0594

References
1	Potential roles of gut microbiome and metabolites in modulating ALS in mice. Nature. 2019 Aug;572(7770):474-480. doi: 10.1038/s41586-019-1443-5. Epub 2019 Jul 22.
2	Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn's Disease. Digestion. 2016;93(1):59-65. doi: 10.1159/000441768. Epub 2016 Jan 14.
3	Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome. World J Gastroenterol. 2010 Sep 28;16(36):4532-40. doi: 10.3748/wjg.v16.i36.4532.
4	Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium.Genome Biol. 2020 Mar 11;21(1):64. doi: 10.1186/s13059-020-01976-7.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.