Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01189)
MIC Name Slackia exigua (actinobacteria)
MIC Synonyms Eubacterium exiguum
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Coriobacteriia
Order: Eggerthellales
Family: Eggerthellaceae
Genus: Slackia
Species: Slackia exigua
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Asaccharolytic; Nonfermentative
Gram Positive
Genome Size (bp) 2094589
Description Slackia exigua is a species of an obligate anaerobic, Gram positive, rod belongs to the family of Coriobacteriacaeae. It is part of human oral microbiota associated with periprosthetic joint infection of the hip.
External Links Taxonomy ID
84109
Genome Assembly ID
ASM16287v1
GOLD Organism ID
Go0003422
Disease Relevance
          Meningococcal disease  [ICD-11: 1C1C]
             Description Slackia exigua was associated with bacteraemia. [1]
Host Genetic Factors (HGFs)
          AMY1A
             HGF ID HGF2311 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description Gut microbiome Coriobacteriaceae differs between high AMY1-CN and low AMY1-CN groups at the OTU Level (p-value<0.05). [2]
          rs6692744
             HGF ID HGF2273 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs6692744 SNP was associated with the relative abundance of Slackia (p-value=3.03E-08). [3]
          rs5030728
             HGF ID HGF1280 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The variant gene TLR4 of innate immunity rs5030728 is significantly associated with the abundance of gut micriobiota Slackia (p-value=0.0128). [4]
          rs36082470
             HGF ID HGF1580 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs36082470 SNP was significantly associated with the relative abundance of Slackia (p-value=2.44E-09). [3]
          rs10202734
             HGF ID HGF1617 HGF Info       Class Single Nucleotide Polymorphism: Upstream variant (SNP-UV)
             Description The rs10202734 SNP was significantly associated with the relative abundance of Slackia (p-value=2.82E-10). [3]
Environmental Factor(s)
             Disbiome ID
      332
             gutMDisorder ID
      gm0604
References
1 Bacteremia caused by Slackia exigua: A report of two cases and literature review. J Infect Chemother. 2020 Jan;26(1):119-123. doi: 10.1016/j.jiac.2019.06.006. Epub 2019 Jul 9.
2 Human Salivary Amylase Gene Copy Number Impacts Oral and Gut Microbiomes.Cell Host Microbe. 2019 Apr 10;25(4):553-564.e7. doi: 10.1016/j.chom.2019.03.001.
3 Association of host genome with intestinal microbial composition in a large healthy cohort.Nat Genet. 2016 Nov;48(11):1413-1417. doi: 10.1038/ng.3693. Epub 2016 Oct 3.
4 Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.

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