General Information of MIC (ID: MIC01297)
MIC Name	Synergistetes (bacteria)
MIC Synonyms	Synergistaeota
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Synergistetes
Oxygen Sensitivity	Anaerobe
Microbial Metabolism	Saccharolytic; Fermentative
Gram	Negative
Description	The Synergistetes is a recently recognized phylum of anaerobic bacteria that shows Gram-negative staining and have rod/vibrioid cell shape. The Synergistetes inhabits a majority of anaerobic environments including animal gastrointestinal tracts, soil, oil wells, and wastewater treatment plants and they are also present in sites of human diseases such as cysts, abscesses, and areas of periodontal disease.
External Links	Taxonomy ID	508458
	GOLD Organism ID	Go0019076
Disease Relevance
Irritable bowel syndrome  [ICD-11: DD91]
Description	Numbers of Synergistetes significantly increased in irritable bowel syndrome than control.				[1]
Periodontal disease  [ICD-11: DA0C]
Description	The metabolomic discovery of 2 novel cyclodipeptides that have been reported to serve as quorum-sensing and/or bacteriocidal/bacteriostatic molecules, in association with Synergistetes, suggests a potential role in periodontal biofilm dysbiosis and periodontal disease that warrants further investigation.				[2]

Host Genetic Factors (HGFs)
rs516246
HGF ID	HGF1582	HGF Info	Class	Single Nucleotide Polymorphism: Non coding transcript variant (SNP-NCTV)
Description	The rs516246 SNP was significantly associated with the abundance of Synergistetes (p-value=0.01025).				[3]

Host Immune Factors (HIFs)
Tumor necrosis factor
HIF ID	HIFM0226	HIF Info	Class	Cytokine (Cyt)
Description	Synergistetes is evidently a minority phylum in human feces with an abundance of 0.01% and its negative correlation (p=0.658, p=0.011) to TNF-a may indicate an important anti-inflammatory factor in healthy population.				[4]

Environmental Factor(s)
Disbiome ID			527
gutMDisorder ID			gm0634

References
1	The gut microbiota and irritable bowel syndrome: friend or foe. Int J Inflam. 2012;2012:151085. doi: 10.1155/2012/151085. Epub 2012 Apr 22.
2	Association of Synergistetes and Cyclodipeptides with Periodontitis. J Dent Res. 2015 Oct;94(10):1425-31. doi: 10.1177/0022034515594779. Epub 2015 Jul 21.
3	FUT2 genotype and secretory status are not associated with fecal microbial composition and inferred function in healthy subjects.Gut Microbes. 2018 Jul 4;9(4):357-368. doi: 10.1080/19490976.2018.1445956. Epub 2018 Apr 27.
4	Clinical intervention using Bifidobacterium strains in celiac disease children reveals novel microbial modulators of TNF- and short-chain fatty acids. Clin Nutr. 2019 Jun;38(3):1373-1381. doi: 10.1016/j.clnu.2018.06.931. Epub 2018 Jun 18.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.