| General Information of MIC (ID: MIC01921) |
| MIC Name |
Mucispirillum schaedleri (bacteria)
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| Body Site |
Gut
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| Lineage |
Kingdom: Bacteria
Phylum: Deferribacteres
Class: Deferribacteres
Order: Deferribacterales
Family: Deferribacteraceae
Genus: Mucispirillum
Species: Mucispirillum schaedleri
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| Oxygen Sensitivity |
Anaerobe
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| Microbial Metabolism |
Fermentative
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| Gram |
Negative
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| Host Relationship |
Pathogen; Commensal
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| Description |
Mucispirillum schaedleri is an abundant inhabitant of the intestinal mucus layer of rodents and other animals and has been suggested to be a pathobiont that plays a role in disease.
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| External Links |
Taxonomy ID |
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| Genome Assembly ID |
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| GOLD Organism ID |
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| Host Genetic Factors (HGFs) |
| SMARCAD1 |
| HGF ID |
HGF2342 |
HGF Info
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Class |
Copy Number Variation: Gene Deletion (CNV-GDe) |
| Description |
The deletion of SMARCAD1 was significantly associated with a decrease of Mucispirillum schaedleri (p-value<0.05). |
[1] |
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| Host Immune Factors (HIFs) |
| CD103+Helios CD4+CD25+FOXP3+ regulatory T cells |
| HIF ID |
HIFC0186 |
HIF Info
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Class |
T cells (TCs) |
| Description |
Mucispirillum schaedleri is related to the expansion of colonic CD103+HeliosCD4+CD25+FOXP3+ Treg cell population. |
[2] |
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| Environmental Factor(s) |
| Disbiome ID |
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| References |
| 1 |
Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium.Genome Biol. 2020 Mar 11;21(1):64. doi: 10.1186/s13059-020-01976-7.
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| 2 |
Development and maintenance of intestinal regulatory T cells.Nat Rev Immunol. 2016 May;16(5):295-309. doi: 10.1038/nri.2016.36. Epub 2016 Apr 18.
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