Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01956)
MIC Name Lachnospira pectinoschiza (firmicutes)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Lachnospira
Species: Lachnospira pectinoschiza
Oxygen Sensitivity Anaerobe
Microbial Metabolism Fermentative
Gram Negative
Description Lachnospira pectinoschiza is a Gram-negative, anaerobic bacterium.
External Links Taxonomy ID
28052
Genome Assembly ID
IMG-taxon 2657245269 annotated assembly
GOLD Organism ID
Go0449795
Disease Relevance
          Irritable bowel syndrome  [ICD-11: DD91]
             Description The level of Lachnospira was significantly increased in irritable bowel syndrome patients than in healthy controls [1]
Host Genetic Factors (HGFs)
          C4B
             HGF ID HGF2348 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description The low C4B-CN has been significantly associated with the high abundance of Lachnospira pectinoschiza (p-value<0.05). [2]
          AVP
             HGF ID HGF2328 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of AVP could significantly increase relative abundances of Lachnospira spp. (p-value<0.05). [3]
          rs493456
             HGF ID HGF1422 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description Gut microbiome Faecalibacterium prausnitzii differs between high AMY1-CN and low AMY1-CN groups at the OTU Level (p-value<0.05). [4]
          rs59846192
             HGF ID HGF2277 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs59846192 SNP was associated with the relative abundance of Lachnospira (p-value=4.15E-08). [5]
          rs2975760
             HGF ID HGF1885 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The variant gene CAPN10 of innate immunity rs2975760 is significantly associated with the abundance of gut micriobiota Lachnospira (p-value=0.0169). [6]
Host Immune Factors (HIFs)
          CD16+ Natural Killer cells
             HIF ID HIFC0094 HIF Info       Class Natural killer cells (NKCs)
             Description The increased proportion of CD16+ NK cells was associated with the decrease of gut commensal bacteria(Lachnospira). [7]
Environmental Factor(s)
             Disbiome ID
      13
             gutMDisorder ID
      gm0384
References
1 Identification of Gut Microbiota and Metabolites Signature in Patients With Irritable Bowel Syndrome. Front Cell Infect Microbiol. 2019 Oct 18;9:346. doi: 10.3389/fcimb.2019.00346. eCollection 2019.
2 C4B gene influences intestinal microbiota through complement activation in patients with paediatric-onset inflammatory bowel disease.Clin Exp Immunol. 2017 Dec;190(3):394-405. doi: 10.1111/cei.13040. Epub 2017 Sep 25.
3 Vasopressin deletion is associated with sex-specific shifts in the gut microbiome.Gut Microbes. 2018 Jan 2;9(1):13-25. doi: 10.1080/19490976.2017.1356557. Epub 2017 Aug 11.
4 Genetic Determinants of the Gut Microbiome in UK Twins.Cell Host Microbe. 2016 May 11;19(5):731-43. doi: 10.1016/j.chom.2016.04.017.
5 Association of host genome with intestinal microbial composition in a large healthy cohort.Nat Genet. 2016 Nov;48(11):1413-1417. doi: 10.1038/ng.3693. Epub 2016 Oct 3.
6 Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
7 Dysbiosis of gut microbiome affecting small intestine morphology and immune balance: a rhesus macaque model.Zool Res. 2020 Jan 18;41(1):20-31. doi: 10.24272/j.issn.2095-8137.2020.004.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.