TTD | Drug: D09RKA

Drug General Information
Drug ID	D09RKA
Former ID	DIB020894
Drug Name	santacruzamate A
Synonyms	CAY10683
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[532523]
Formula	C15H22N2O3
InChI	InChI=1S/C15H22N2O3/c1-2-20-15(19)17-11-6-9-14(18)16-12-10-13-7-4-3-5-8-13/h3-5,7-8H,2,6,9-12H2,1H3,(H,16,18)(H,17,19)
InChIKey	HTOYBIILVCHURC-UHFFFAOYSA-N
PubChem Compound ID	72946782
Target and Pathway
Target(s)	Histone deacetylase 2	Target Info	Inhibitor	[532523]
	Histone deacetylase 4	Target Info	Inhibitor	[532523]
	Histone deacetylase 6	Target Info	Inhibitor	[532523]
KEGG Pathway	Cell cycle
	Notch signaling pathway
	Thyroid hormone signaling pathway
	Huntington's disease
	Alcoholism
	Epstein-Barr virus infection
	Pathways in cancer
	Transcriptional misregulation in cancer
	Viral carcinogenesis
	Chronic myeloid leukemiahsa05034:Alcoholism
	MicroRNAs in cancerhsa05034:Alcoholism
NetPath Pathway	TCR Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway	Wnt signaling pathway
Pathway Interaction Database	Regulation of nuclear SMAD2/3 signaling
	Signaling events mediated by HDAC Class I
	Regulation of Telomerase
	Glucocorticoid receptor regulatory network
	Direct p53 effectors
	Hedgehog signaling events mediated by Gli proteins
	Regulation of nuclear beta catenin signaling and target gene transcriptionhdac_classii_pathway:Signaling events mediated by HDAC Class II
	Signaling events mediated by HDAC Class III
	Sumoylation by RanBP2 regulates transcriptional repression
	Validated nuclear estrogen receptor alpha networkhdac_classii_pathway:Signaling events mediated by HDAC Class II
Reactome	p75NTR negatively regulates cell cycle via SC1
	NOTCH1 Intracellular Domain Regulates Transcription
	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	HDACs deacetylate histones
	NoRC negatively regulates rRNA expression
	RNA Polymerase I Transcription Initiation
	Factors involved in megakaryocyte development and platelet productionR-HSA-2122947:NOTCH1 Intracellular Domain Regulates Transcription
	Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsR-HSA-2122947:NOTCH1 Intracellular Domain Regulates Transcription
	Assembly of the primary cilium
WikiPathways	Notch Signaling Pathway
	Notch Signaling Pathway
	Neural Crest Differentiation
	Signalling by NGF
	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
	Factors involved in megakaryocyte development and platelet production
	Cell CycleWP474:Endochondral Ossification
	Cardiac Hypertrophic Response
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	TarBasePathway
	Cell Cycle
	MicroRNAs in cardiomyocyte hypertrophyWP2858:Ectoderm Differentiation
References
Ref 532523	Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J Nat Prod. 2013 Nov 22;76(11):2026-33.
Ref 532523	Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J Nat Prod. 2013 Nov 22;76(11):2026-33.

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Drug Information