TTD | Drug: D0V2ZO

Drug General Information
Drug ID	D0V2ZO
Former ID	DNC004602
Drug Name	5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527056]
Formula	C11H14ClNO2
Canonical SMILES	C1=CC(=CC=C1CCCCC(=O)NO)Cl
InChI	1S/C11H14ClNO2/c12-10-7-5-9(6-8-10)3-1-2-4-11(14)13-15/h5-8,15H,1-4H2,(H,13,14)
InChIKey	PRMXJXDYJXBBPT-UHFFFAOYSA-N
PubChem Compound ID	11528707
Target and Pathway
Target(s)	Histone Deacetylase 8	Target Info	Inhibitor	[527056]
	Histone deacetylase 1	Target Info	Inhibitor	[527056]
	Histone deacetylase 6	Target Info	Inhibitor	[527056]
	Histone deacetylase 4	Target Info	Inhibitor	[527056]
	Histone deacetylase	Target Info	Inhibitor	[527056]
	Histone deacetylase 2	Target Info	Inhibitor	[527056]
	Histone Deacetylase 10	Target Info	Inhibitor	[527056]
KEGG Pathway	Alcoholism
	Viral carcinogenesishsa04110:Cell cycle
	Notch signaling pathway
	Thyroid hormone signaling pathway
	Huntington's disease
	Amphetamine addiction
	Epstein-Barr virus infection
	Pathways in cancer
	Transcriptional misregulation in cancer
	Viral carcinogenesis
	MicroRNAs in cancer
	Chronic myeloid leukemiahsa05034:Alcoholism
	Viral carcinogenesishsa05034:Alcoholism
	MicroRNAs in cancerhsa04110:Cell cycle
	Chronic myeloid leukemia
NetPath Pathway	TCR Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_11:TCR Signaling Pathway
PANTHER Pathway	Wnt signaling pathwayP00057:Wnt signaling pathway
PANTHER Pathway	p53 pathwayP00057:Wnt signaling pathway
Pathway Interaction Database	Signaling events mediated by HDAC Class Ismad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
	Notch signaling pathway
	E2F transcription factor network
	Presenilin action in Notch and Wnt signaling
	Signaling events mediated by HDAC Class I
	Regulation of Telomerase
	Glucocorticoid receptor regulatory network
	Sumoylation by RanBP2 regulates transcriptional repression
	Regulation of Androgen receptor activity
	IL3-mediated signaling events
	Validated nuclear estrogen receptor alpha network
	Retinoic acid receptors-mediated signaling
	Hedgehog signaling events mediated by Gli proteins
	Regulation of nuclear beta catenin signaling and target gene transcription
	Validated targets of C-MYC transcriptional repression
	Regulation of retinoblastoma protein
	Notch-mediated HES/HEY networkhdac_classii_pathway:Signaling events mediated by HDAC Class II
	Signaling events mediated by HDAC Class Ihdac_classii_pathway:Signaling events mediated by HDAC Class II
	Signaling events mediated by HDAC Class III
	Validated nuclear estrogen receptor alpha networksmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
	Direct p53 effectors
	Regulation of nuclear beta catenin signaling and target gene transcriptionhdac_classii_pathway:Signaling events mediated by HDAC Class II
Reactome	NOTCH1 Intracellular Domain Regulates Transcription
	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	HDACs deacetylate histonesR-HSA-1538133:G0 and Early G1
	p75NTR negatively regulates cell cycle via SC1
	Formation of the beta-catenin:TCF transactivating complex
	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
	HDACs deacetylate histones
	Deactivation of the beta-catenin transactivating complex
	NoRC negatively regulates rRNA expression
	RNA Polymerase I Transcription Initiation
	Factors involved in megakaryocyte development and platelet productionR-HSA-2122947:NOTCH1 Intracellular Domain Regulates Transcription
	Assembly of the primary ciliumR-HSA-2122947:NOTCH1 Intracellular Domain Regulates Transcription
	Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsR-HSA-193670:p75NTR negatively regulates cell cycle via SC1
	Factors involved in megakaryocyte development and platelet production
WikiPathways	Integrated Pancreatic Cancer Pathway
	Neural Crest Differentiation
	Cell CycleWP706:SIDS Susceptibility Pathways
	Notch Signaling Pathway
	TGF beta Signaling Pathway
	IL-6 signaling pathway
	Apoptosis-related network due to altered Notch3 in ovarian cancer
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Notch Signaling Pathway
	Retinoblastoma (RB) in Cancer
	TWEAK Signaling Pathway
	Integrated Breast Cancer Pathway
	Signalling by NGF
	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
	Mitotic G1-G1/S phases
	Factors involved in megakaryocyte development and platelet production
	Cell Cycle
	Androgen receptor signaling pathwayWP2858:Ectoderm Differentiation
	Cell CycleWP474:Endochondral Ossification
	Cardiac Hypertrophic Response
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	TarBasePathway
	MicroRNAs in cardiomyocyte hypertrophyWP61:Notch Signaling Pathway
References
Ref 527056	Bioorg Med Chem Lett. 2004 May 17;14(10):2477-81.Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides.
Ref 527056	Bioorg Med Chem Lett. 2004 May 17;14(10):2477-81.Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides.

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Drug Information