Drug Information

Drug General Information
Drug ID
D09TSC
Former ID
DNC011860
Drug Name
Ro-32-0557
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551264]
Formula
C28H27ClN4O2
Canonical SMILES
CN1CC2CC3=C(C4=CC=CC=C4N3CC2C1)C5=C(C(=O)NC5=O)C6=CN(C7<br />=CC=CC=C76)C.Cl
InChI
1S/C28H26N4O2.ClH/c1-30-12-16-11-23-24(19-8-4-6-10-22(19)32(23)14-17(16)13-30)26-25(27(33)29-28(26)34)20-15-31(2)21-9-5-3-7-18(20)21;/h3-10,15-17H,11-14H2,1-2H3,(H,29,33,34);1H
InChIKey
VAPUWJSPUKOQCG-UHFFFAOYSA-N
PubChem Compound ID
45264052
Target and Pathway
Target(s) Protein kinase C, theta type Target Info Inhibitor [551264]
Protein kinase C gamma type Target Info Inhibitor [551264]
Protein kinase C, zeta type Target Info Inhibitor [551264]
Protein kinase C, alpha type Target Info Inhibitor [551264]
Protein kinase C, beta type Target Info Inhibitor [551264]
Protein kinase C, epsilon type Target Info Inhibitor [551264]
Protein kinase C, delta type Target Info Inhibitor [551264]
KEGG Pathway NF-kappa B signaling pathway
Vascular smooth muscle contraction
Tight junction
T cell receptor signaling pathway
Inflammatory mediator regulation of TRP channels
Adipocytokine signaling pathway
Measleshsa04010:MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
mTOR signaling pathway
Wnt signaling pathway
VEGF signaling pathway
Focal adhesion
Gap junction
Natural killer cell mediated cytotoxicity
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Long-term depression
Insulin secretion
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Amphetamine addiction
Morphine addiction
Vibrio cholerae infection
African trypanosomiasis
Amoebiasis
Hepatitis B
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Choline metabolism in cancerhsa04015:Rap1 signaling pathway
Chemokine signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Hippo signaling pathway
Platelet activation
Insulin signaling pathway
Type II diabetes mellitushsa04010:MAPK signaling pathway
Adrenergic signaling in cardiomyocytes
Fc epsilon RI signaling pathway
GnRH signaling pathway
Pathogenic Escherichia coli infection
Influenza A
Choline metabolism in cancerhsa04010:MAPK signaling pathway
B cell receptor signaling pathway
Carbohydrate digestion and absorption
Leishmaniasis
Choline metabolism in cancerhsa04022:cGMP-PKG signaling pathway
Type II diabetes mellitus
MicroRNAs in cancerhsa04062:Chemokine signaling pathway
Neurotrophin signaling pathway
Estrogen signaling pathway
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Angiogenesis
Apoptosis signaling pathway
EGF receptor signaling pathway
Endothelin signaling pathway
FGF signaling pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
T cell activation
VEGF signaling pathway
Wnt signaling pathway
5HT2 type receptor mediated signaling pathway
Histamine H1 receptor mediated signaling pathway
Oxytocin receptor mediated signaling pathway
Thyrotropin-releasing hormone receptor signaling pathway
CCKR signaling map STP00002:Alpha adrenergic receptor signaling pathway
Thyrotropin-releasing hormone receptor signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Inflammation mediated by chemokine and cytokine signaling pathway
Thyrotropin-releasing hormone receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
PDGF signaling pathway
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
B cell activation
Metabotropic glutamate receptor group I pathway
CCKR signaling map ST
Pathway Interaction Database Endothelins
TCR signaling in na&#xef
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
TCR signaling in na&#xef
Thromboxane A2 receptor signaling
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Downstream signaling in na&#xef
Endothelins
Retinoic acid receptors-mediated signaling
IL8- and CXCR2-mediated signaling events
PAR1-mediated thrombin signaling events
IL8- and CXCR1-mediated signaling eventsrhoa_pathway:RhoA signaling pathway
Insulin Pathway
Noncanonical Wnt signaling pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
CDC42 signaling events
IL1-mediated signaling events
CXCR4-mediated signaling events
IGF1 pathway
TNF receptor signaling pathway
IL2 signaling events mediated by PI3K
Ceramide signaling pathway
p75(NTR)-mediated signaling
amb2 Integrin signaling
ErbB1 downstream signaling
Neurotrophic factor-mediated Trk receptor signaling
Nephrin/Neph1 signaling in the kidney podocyte
Insulin-mediated glucose transport
Regulation of Ras family activationendothelinpathway:Endothelins
Canonical NF-kappaB pathway
Signaling events regulated by Ret tyrosine kinase
mTOR signaling pathway
Ras signaling in the CD4+ TCR pathway
Syndecan-4-mediated signaling events
ATF-2 transcription factor network
PDGFR-beta signaling pathway
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2
a6b1 and a6b4 Integrin signaling
IL8- and CXCR1-mediated signaling events
Regulation of Ras family activation
Fc-epsilon receptor I signaling in mast cells
IL2-mediated signaling events
JNK signaling in the CD4+ TCR pathway
LPA receptor mediated events
LPA4-mediated signaling events
IFN-gamma pathway
IL6-mediated signaling events
Hedgehog signaling events mediated by Gli proteins
Syndecan-2-mediated signaling events
Validated transcriptional targets of TAp63 isoforms
p53 pathway
Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Alpha-synuclein signaling
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000453:Fc Epsilon Receptor I Signaling in Mast Cells
Activation of PKC through G protein coupled receptor
Reactome Apoptotic cleavage of cellular proteins
Effects of PIP2 hydrolysis
Inactivation, recovery and regulation of the phototransduction cascade
FCERI mediated NF-kB activation
G alpha (z) signalling eventsR-HSA-111933:Calmodulin induced events
Disinhibition of SNARE formation
Trafficking of GluR2-containing AMPA receptors
G alpha (z) signalling events
WNT5A-dependent internalization of FZD4
Response to elevated platelet cytosolic Ca2+R-HSA-114604:GPVI-mediated activation cascade
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
VEGFR2 mediated cell proliferationR-HSA-111933:Calmodulin induced events
Regulation of KIT signaling
EGFR Transactivation by Gastrin
Syndecan interactions
Acetylcholine regulates insulin secretion
Ca2+ pathway
Depolymerisation of the Nuclear Lamina
HuR (ELAVL1) binds and stabilizes mRNA
VEGFR2 mediated cell proliferation
Response to elevated platelet cytosolic Ca2+R-HSA-114516:Disinhibition of SNARE formation
Activation of NF-kappaB in B cells
Response to elevated platelet cytosolic Ca2+R-HSA-114508:Effects of PIP2 hydrolysis
DAG and IP3 signaling
Role of phospholipids in phagocytosis
G alpha (z) signalling eventsR-HSA-111465:Apoptotic cleavage of cellular proteins
Calmodulin induced events
CLEC7A (Dectin-1) signaling
Interferon gamma signaling
WikiPathways TCR Signaling Pathway
Calcium Regulation in the Cardiac Cell
Insulin Signaling
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Fc epsilon receptor (FCERI) signaling
Corticotropin-releasing hormone
Signaling Pathways in Glioblastoma
miRs in Muscle Cell Differentiation
TCR signaling
Netrin-1 signaling
GPCR downstream signaling
Effects of PIP2 hydrolysis
Apoptotic execution phaseWP536:Calcium Regulation in the Cardiac Cell
MAPK Signaling Pathway
Wnt Signaling Pathway Netpath
DAG and IP3 signaling
Opioid Signalling
Response to elevated platelet cytosolic Ca2+WP536:Calcium Regulation in the Cardiac Cell
EGF/EGFR Signaling Pathway
Signaling by TGF-beta Receptor Complex
Allograft Rejection
AGE/RAGE pathway
TNF alpha Signaling Pathway
IL-1 signaling pathway
GPVI-mediated activation cascade
Type II diabetes mellitusWP673:ErbB Signaling Pathway
Kit receptor signaling pathway
Transcriptional activation by NRF2
Human Complement System
Cardiac Hypertrophic Response
Syndecan interactions
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
Signaling by SCF-KIT
Gastrin-CREB signalling pathway via PKC and MAPK
T-Cell Receptor and Co-stimulatory Signaling
Alpha 6 Beta 4 signaling pathway
Spinal Cord Injury
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Pathogenic Escherichia coli infection
Endothelin Pathways
Regulation of Microtubule Cytoskeleton
FSH signaling pathway
Response to elevated platelet cytosolic Ca2+
Integration of energy metabolism
TOR SignalingWP536:Calcium Regulation in the Cardiac Cell
Signaling by the B Cell Receptor (BCR)
B Cell Receptor Signaling Pathway
MicroRNAs in cardiomyocyte hypertrophy
Physiological and Pathological Hypertrophy of the HeartWP666:Hypothetical Network for Drug Addiction
Physiological and Pathological Hypertrophy of the HeartWP69:TCR Signaling Pathway
Type II interferon signaling (IFNG)
IL-6 signaling pathway
BDNF signaling pathway
Apoptotic execution phase
Type II diabetes mellitus
References
Ref 551264Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain, Bioorg. Med. Chem. Lett. 4(11):1303-1308 (1994).
Ref 551264Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain, Bioorg. Med. Chem. Lett. 4(11):1303-1308 (1994).

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