TTD | Drug: D09XIL

Drug General Information
Drug ID	D09XIL
Former ID	DNC006432
Drug Name	Ro-4396686
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528018]
Formula	C24H24FN5O3
Canonical SMILES	COC1=CC=C(C=C1)N2CC3=CN=C(N=C3N(C2=O)C4CCC(C4)O)NC5=CC=<br />C(C=C5)F
InChI	1S/C24H24FN5O3/c1-33-21-10-7-18(8-11-21)29-14-15-13-26-23(27-17-4-2-16(25)3-5-17)28-22(15)30(24(29)32)19-6-9-20(31)12-19/h2-5,7-8,10-11,13,19-20,31H,6,9,12,14H2,1H3,(H,26,27,28)
InChIKey	KXEMINRANVTICS-UHFFFAOYSA-N
PubChem Compound ID	11396738
Target and Pathway
Target(s)	FGF-3 receptor	Target Info	Inhibitor	[528018]
	Alpha platelet-derived growth factor receptor	Target Info	Inhibitor	[528018]
	Fibroblast growth factor receptor 2	Target Info	Inhibitor	[528018]
	Vascular endothelial growth factor receptor 2	Target Info	Inhibitor	[528018]
	mRNA of FGFR4	Target Info	Inhibitor	[528018]
	mRNA of PKA Catalytic Subunit C-alpha	Target Info	Inhibitor	[528018]
	Fyn tyrosine kinase	Target Info	Inhibitor	[528018]
	CAMP-dependent protein kinase type II-beta regulatory chain	Target Info	Inhibitor	[528018]
	Protein kinase A	Target Info	Inhibitor	[528018]
	Beta platelet-derived growth factor receptor	Target Info	Inhibitor	[528018]
	Basic fibroblast growth factor receptor 1	Target Info	Inhibitor	[528018]
	Mitogen-activated protein kinase 1	Target Info	Inhibitor	[528018]
	Epidermal growth factor receptor	Target Info	Inhibitor	[528018]
KEGG Pathway	MAPK signaling pathway
	Ras signaling pathway
	Rap1 signaling pathway
	Endocytosis
	PI3K-Akt signaling pathway
	Signaling pathways regulating pluripotency of stem cells
	Regulation of actin cytoskeleton
	Pathways in cancer
	MicroRNAs in cancer
	Bladder cancer
	Central carbon metabolism in cancerhsa04010:MAPK signaling pathway
	Calcium signaling pathway
	Cytokine-cytokine receptor interaction
	Focal adhesion
	Gap junction
	HTLV-I infection
	Glioma
	Prostate cancer
	Melanoma
	Central carbon metabolism in cancer
	Choline metabolism in cancerhsa04010:MAPK signaling pathway
	Central carbon metabolism in cancerhsa04014:Ras signaling pathway
	VEGF signaling pathway
	Proteoglycans in cancerhsa04010:MAPK signaling pathway
	Regulation of actin cytoskeletonhsa04010:MAPK signaling pathway
	cAMP signaling pathway
	Chemokine signaling pathway
	Oocyte meiosis
	Apoptosis
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Wnt signaling pathway
	Hedgehog signaling pathway
	Platelet activation
	Circadian entrainment
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Cholinergic synapse
	Serotonergic synapse
	GABAergic synapse
	Dopaminergic synapse
	Olfactory transduction
	Taste transduction
	Inflammatory mediator regulation of TRP channels
	Insulin signaling pathway
	Insulin secretion
	GnRH signaling pathway
	Ovarian steroidogenesis
	Progesterone-mediated oocyte maturation
	Estrogen signaling pathway
	Melanogenesis
	Thyroid hormone synthesis
	Thyroid hormone signaling pathway
	Oxytocin signaling pathway
	Glucagon signaling pathway
	Regulation of lipolysis in adipocytes
	Renin secretion
	Endocrine and other factor-regulated calcium reabsorption
	Vasopressin-regulated water reabsorption
	Salivary secretion
	Gastric acid secretion
	Bile secretion
	Parkinson's disease
Prion diseases
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholism
Vibrio cholerae infection
Amoebiasis
Epstein-Barr virus infection
Viral carcinogenesis
Proteoglycans in cancer
Dilated cardiomyopathyhsa04071:Sphingolipid signaling pathway
Axon guidance
Osteoclast differentiation
Adherens junction
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Pathogenic Escherichia coli infection
Measles
Viral myocarditishsa04210:Apoptosis
Insulin signaling pathwayhsa04010:MAPK signaling pathway
ErbB signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
mTOR signaling pathway
Dorso-ventral axis formation
TGF-beta signaling pathway
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
B cell receptor signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Neurotrophin signaling pathway
Long-term depression
Prolactin signaling pathway
Type II diabetes mellitus
Aldosterone-regulated sodium reabsorption
Alzheimer's disease
Shigellosis
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Thyroid cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Epithelial cell signaling in Helicobacter pylori infection
Choline metabolism in cancer
NetPath Pathway	TGF_beta_Receptor Signaling PathwayNetPath_13:IL1 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_23:TSH Signaling Pathway
	IL2 Signaling Pathway
	TGF_beta_Receptor Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_16:IL4 Signaling Pathway
	EGFR1 Signaling Pathway
PANTHER Pathway	FGF signaling pathwayP00005:Angiogenesis
	PDGF signaling pathwayP00021:FGF signaling pathwayP00005:Angiogenesis
	VEGF signaling pathwayP00021:FGF signaling pathwayP00019:Endothelin signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
	Inflammation mediated by chemokine and cytokine signaling pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group II pathway
	Metabotropic glutamate receptor group I pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathway
	5HT1 type receptor mediated signaling pathway
	Beta1 adrenergic receptor signaling pathway
	Beta2 adrenergic receptor signaling pathway
	Histamine H2 receptor mediated signaling pathway
	GABA-B receptor II signaling
	Dopamine receptor mediated signaling pathway
	Enkephalin release
	Nicotine pharmacodynamics pathway
	CCKR signaling map STP00007:Axon guidance mediated by semaphorins
	Cadherin signaling pathway
	Integrin signalling pathway
	Parkinson diseaseP00019:Endothelin signaling pathway
	Hedgehog signaling pathway
	Transcription regulation by bZIP transcription factor
	Enkephalin releaseP00005:Angiogenesis
	PDGF signaling pathwayP00005:Angiogenesis
	FGF signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Angiogenesis
	Apoptosis signaling pathway
	B cell activation
	EGF receptor signaling pathway
	Endothelin signaling pathway
	FGF signaling pathway
	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
	Interferon-gamma signaling pathway
	Interleukin signaling pathway
	PDGF signaling pathway
	Parkinson disease
	TGF-beta signaling pathway
	T cell activation
	VEGF signaling pathway
	Ras Pathway
	Angiotensin II-stimulated signaling through G proteins and beta-arrestin
	CCKR signaling map STP00012:Cadherin signaling pathway
Pathway Interaction Database	ATF-2 transcription factor network
	PDGFR-alpha signaling pathway
	PDGF receptor signaling networkfgf_pathway:FGF signaling pathwayhif2pathway:HIF-2-alpha transcription factor network
	Beta3 integrin cell surface interactions
	Signaling events mediated by TCPTP
	SHP2 signaling
	S1P1 pathway
	VEGF and VEGFR signaling network
	Integrins in angiogenesis
	Signaling events mediated by VEGFR1 and VEGFR2
	Notch-mediated HES/HEY networkfgf_pathway:FGF signaling pathwaygmcsf_pathway:GMCSF-mediated signaling events
	LPA4-mediated signaling events
	Signaling events regulated by Ret tyrosine kinase
	LKB1 signaling events
	Thromboxane A2 receptor signaling
	Signaling events mediated by HDAC Class I
	Role of Calcineurin-dependent NFAT signaling in lymphocytes
	Glucocorticoid receptor regulatory network
	ErbB2/ErbB3 signaling events
	IL3-mediated signaling events
	Syndecan-1-mediated signaling events
	Retinoic acid receptors-mediated signaling
	Hedgehog signaling events mediated by Gli proteins
	VEGFR1 specific signals
	Calcium signaling in the CD4+ TCR pathway
	Syndecan-2-mediated signaling events
	Aurora A signaling
	Class I PI3K signaling events mediated by Akt
	Alpha4 beta1 integrin signaling eventsfcer1pathway:Fc-epsilon receptor I signaling in mast cells
	ErbB4 signaling events
	Glypican 1 network
	TCR signaling in na&#xef
	Signaling events mediated by PTP1B
	Ephrin A reverse signaling
	Reelin signaling pathway
	Regulation of p38-alpha and p38-beta
	TCR signaling in na&#xef
	Angiopoietin receptor Tie2-mediated signaling
	Netrin-mediated signaling events
	IL2-mediated signaling events
	CXCR4-mediated signaling events
	Class I PI3K signaling events
	Posttranslational regulation of adherens junction stability and dissassembly
	amb2 Integrin signaling
	EPHA forward signaling
	E-cadherin signaling in keratinocytes
	PDGFR-beta signaling pathway
	Nephrin/Neph1 signaling in the kidney podocyte
	Syndecan-3-mediated signaling events
	Ephrin B reverse signaling
	Alpha-synuclein signaling
	Signaling events mediated by focal adhesion kinaseptp1bpathway:Signaling events mediated by PTP1B
	S1P3 pathway
	Nectin adhesion pathway
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	Validated targets of C-MYC transcriptional repression
	PDGF receptor signaling networkglypican_1pathway:Glypican 1 network
	Syndecan-4-mediated signaling events
	N-cadherin signaling events
	FGF signaling pathwayfcer1pathway:Fc-epsilon receptor I signaling in mast cells
	Endothelins
	BCR signaling pathway
	Signaling events mediated by PRL
	GMCSF-mediated signaling events
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
EPHB forward signaling
Osteopontin-mediated events
S1P4 pathway
Presenilin action in Notch and Wnt signaling
TRAIL signaling pathway
CDC42 signaling events
Regulation of Telomerase
Arf6 downstream pathway
mTOR signaling pathway
Class IB PI3K non-lipid kinase events
EGF receptor (ErbB1) signaling pathway
Ras signaling in the CD4+ TCR pathway
Ceramide signaling pathway
IFN-gamma pathway
ErbB1 downstream signaling
BMP receptor signaling
ALK1 signaling events
Neurotrophic factor-mediated Trk receptor signaling
Nongenotropic Androgen signaling
CXCR3-mediated signaling events
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Cellular roles of Anthrax toxin
S1P2 pathway
Trk receptor signaling mediated by the MAPK pathway
Downstream signaling in na&#xef
VEGFR3 signaling in lymphatic endothelium
FGF signaling pathway
Signaling events mediated by focal adhesion kinaselysophospholipid_pathway:LPA receptor mediated events
Arf6 signaling events
EGFR-dependent Endothelin signaling events
Direct p53 effectors
ErbB receptor signaling network
Internalization of ErbB1
Stabilization and expansion of the E-cadherin adherens junction
a6b1 and a6b4 Integrin signaling
PathWhiz Pathway	Muscle/Heart ContractionPW000453:Fc Epsilon Receptor I Signaling in Mast CellsPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
	Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
	Fc Epsilon Receptor I Signaling in Mast Cells
	Insulin Signalling
Reactome	FGFR3 mutant receptor activationR-HSA-1257604:PIP3 activates AKT signaling
	Constitutive Signaling by Aberrant PI3K in Cancer
	RAF/MAP kinase cascadeR-HSA-2033519:Activated point mutants of FGFR2R-HSA-194306:Neurophilin interactions with VEGF and VEGFR
	VEGF binds to VEGFR leading to receptor dimerization
	Integrin cell surface interactions
	EPHA-mediated growth cone collapse
	VEGFA-VEGFR2 Pathway
	VEGFR2 mediated cell proliferationR-HSA-109704:PI3K Cascade
	PIP3 activates AKT signaling
	FGFR4 ligand binding and activation
	Phospholipase C-mediated cascade
	FRS-mediated FGFR4 signaling
	SHC-mediated cascade:FGFR4
	PI-3K cascade:FGFR4
	Negative regulation of FGFR4 signaling
	RAF/MAP kinase cascadeR-HSA-163560:Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
	PKA activation
	PKA activation in glucagon signalling
	DARPP-32 events
	Regulation of PLK1 Activity at G2/M Transition
	Loss of Nlp from mitotic centrosomes
	Recruitment of mitotic centrosome proteins and complexes
	Loss of proteins required for interphase microtubule organization?from the centrosome
	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
	Regulation of insulin secretion
	Vasopressin regulates renal water homeostasis via Aquaporins
	Interleukin-3, 5 and GM-CSF signaling
	Degradation of GLI1 by the proteasome
	Degradation of GLI2 by the proteasome
	Hedgehog 'off' state
	Anchoring of the basal body to the plasma membrane
	CD209 (DC-SIGN) signaling
	MAPK6/MAPK4 signaling
	Gluconeogenesis
	Factors involved in megakaryocyte development and platelet productionR-HSA-114604:GPVI-mediated activation cascade
	Regulation of KIT signaling
	Cell surface interactions at the vascular wall
	FCGR activation
	PECAM1 interactions
	DAP12 signaling
	EPH-Ephrin signaling
	Role of LAT2/NTAL/LAB on calcium mobilization
	Nephrin interactions
	NCAM signaling for neurite out-growth
	CD28 co-stimulation
	CD28 dependent PI3K/Akt signaling
	CD28 dependent Vav1 pathway
	CTLA4 inhibitory signaling
	EPHB-mediated forward signaling
	EPH-ephrin mediated repulsion of cells
	CRMPs in Sema3A signaling
	DCC mediated attractive signaling
	Netrin mediated repulsion signals
	Dectin-2 family
	RAF/MAP kinase cascade
	Platelet Adhesion to exposed collagen
	Regulation of signaling by CBL
	Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-163615:PKA activation
	Factors involved in megakaryocyte development and platelet productionR-HSA-1257604:PIP3 activates AKT signaling
	RAF/MAP kinase cascadeR-HSA-112409:RAF-independent MAPK1/3 activation
	MAPK1 (ERK2) activation
	Golgi Cisternae Pericentriolar Stack Reorganization
	ERK/MAPK targets
	Regulation of actin dynamics for phagocytic cup formation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
Recycling pathway of L1
CREB phosphorylation through the activation of Ras
Activation of the AP-1 family of transcription factors
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
RHO GTPases Activate WASPs and WAVEs
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Signal attenuation
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Growth hormone receptor signalingR-HSA-1236382:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
PLCG1 events in ERBB2 signaling
GRB2 events in EGFR signaling
GAB1 signalosome
SHC1 events in EGFR signaling
EGFR downregulation
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
EGFR Transactivation by Gastrin
Constitutive Signaling by EGFRvIII
WikiPathways	Regulation of Actin Cytoskeleton
	Endochondral Ossification
	Bladder Cancer
	Neural Crest Differentiation
	Signaling by FGFRWP51:Regulation of Actin Cytoskeleton
	Osteoblast Signaling
	Focal Adhesion
	Hair Follicle Development: Organogenesis (Part 2 of 3)
	PIP3 activates AKT signaling
	Cardiac Progenitor Differentiation
	Integrated Pancreatic Cancer Pathway
	Allograft Rejection
	Signaling Pathways in Glioblastoma
	Signaling by PDGF
	AngiogenesisWP51:Regulation of Actin Cytoskeleton
	Ectoderm Differentiation
	Hair Follicle Development: Induction (Part 1 of 3)
	Cardiac Hypertrophic Response
	Signaling by FGFR
	MicroRNAs in cardiomyocyte hypertrophy
	AngiogenesisWP306:Focal Adhesion
	Nifedipine Activity
	Signaling by VEGF
	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
	Signaling by FGFRWP706:SIDS Susceptibility Pathways
	Hypothetical Network for Drug Addiction
	Calcium Regulation in the Cardiac Cell
	MAPK Signaling Pathway
	G Protein Signaling Pathways
	Myometrial Relaxation and Contraction Pathways
	IL-3 Signaling Pathway
	Mesodermal Commitment Pathway
	Human Complement System
	DAG and IP3 signaling
	Regulation of Water Balance by Renal Aquaporins
	Dopamine metabolism
	Regulation of Microtubule Cytoskeleton
	FSH signaling pathway
	miRs in Muscle Cell Differentiation
	SREBP signalling
	Opioid Signalling
	Mitotic G2-G2/M phases
	Integration of energy metabolism
	Factors involved in megakaryocyte development and platelet production
	Nicotine Activity on Dopaminergic NeuronsWP69:TCR Signaling Pathway
	Interferon type I signaling pathways
	IL-2 Signaling Pathway
	Kit receptor signaling pathway
	Fc epsilon receptor (FCERI) signaling
	Signaling by the B Cell Receptor (BCR)
	Signaling by SCF-KIT
	DAP12 interactions
	Host Interactions of HIV factors
	T-Cell Receptor and Co-stimulatory Signaling
	Primary Focal Segmental Glomerulosclerosis FSGS
	BDNF signaling pathway
	Interleukin-11 Signaling Pathway
	B Cell Receptor Signaling Pathway
	Pathogenic Escherichia coli infection
	TSLP Signaling Pathway
	IL-7 Signaling Pathway
	Leptin signaling pathway
	Semaphorin interactions
	Platelet Adhesion to exposed collagen
Netrin-1 signaling
Nephrin interactions
NCAM signaling for neurite out-growth
Integrin-mediated Cell Adhesion
GPVI-mediated activation cascade
Costimulation by the CD28 family
Cell surface interactions at the vascular wallWP706:SIDS Susceptibility Pathways
Factors involved in megakaryocyte development and platelet productionWP51:Regulation of Actin Cytoskeleton
PDGF Pathway
Signaling by PDGFWP51:Regulation of Actin Cytoskeleton
Signaling by FGFRWP75:Toll-like receptor signaling pathway
Serotonin Receptor 4/6/7 and NR3C Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Serotonin HTR1 Group and FOS Pathway
Vitamin A and Carotenoid Metabolism
DNA Damage Response (only ATM dependent)
TCR Signaling Pathway
ErbB Signaling Pathway
Senescence and Autophagy in Cancer
EPO Receptor Signaling
Insulin Signaling
EGF/EGFR Signaling Pathway
MAPK Cascade
IL-4 Signaling Pathway
TGF beta Signaling Pathway
IL-6 signaling pathway
Signaling of Hepatocyte Growth Factor Receptor
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
Apoptosis-related network due to altered Notch3 in ovarian cancer
MAP kinase activation in TLR cascade
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
RAF/MAP kinase cascade
Nanoparticle-mediated activation of receptor signaling
Structural Pathway of Interleukin 1 (IL-1)
Genes and (Common) Pathways Underlying Drug Addiction
EBV LMP1 signaling
Signal Transduction of S1P Receptor
Aryl Hydrocarbon Receptor
Alpha 6 Beta 4 signaling pathway
Spinal Cord Injury
Oncostatin M Signaling Pathway
Corticotropin-releasing hormone
AGE/RAGE pathway
TNF alpha Signaling Pathway
Prostate Cancer
IL-9 Signaling Pathway
Endothelin Pathways
IL17 signaling pathway
Alzheimers Disease
TWEAK Signaling Pathway
RANKL/RANK Signaling Pathway
Integrated Breast Cancer Pathway
IL-1 signaling pathway
Thrombin signalling through proteinase activated receptors (PARs)
L1CAM interactions
Advanced glycosylation endproduct receptor signaling
Heart Development
Type II diabetes mellitus
Angiogenesis
Physiological and Pathological Hypertrophy of the Heart
Regulation of toll-like receptor signaling pathway
Osteopontin Signaling
IL-5 Signaling PathwayWP673:ErbB Signaling Pathway
Aryl Hydrocarbon Receptor Pathway
Extracellular vesicle-mediated signaling in recipient cells
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Signaling by ERBB4
Signaling by ERBB2
Gastrin-CREB signalling pathway via PKC and MAPK
Gastric cancer network 2
Arylhydrocarbon receptor (AhR) signaling pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
Signaling by EGFR
References
Ref 528018	Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. Epub 2006 Feb 3.Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis.
Ref 528018	Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. Epub 2006 Feb 3.Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis.

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Drug Information