Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFC0121)
HIF Name	CX3CR1+ macrophages
HIF Synonym(s)	CX3CR1(+) macrophages, CX3CR1+ macrophages
HIF Classification	Macrophages (Mac)
Description	Moreover, recent intense research efforts of many laboratories have revealed evidence for critical labor division between lamina propria-resident CD103(+)dendriticcellsand CX3CR1(+) macrophages.	[1]

Microbe Species (MIC) Regulated by This HIF
Salmonella enterica subsp. enterica (enterobacteria)		MIC01154
Description	CX3CR1 + macrophages controlled intestinal IgA production in response to Salmonella Typhimurium infection.		[2]
Salmonella sp. (enterobacteria)		MIC01149
Description	Infection with noninvasive Salmonella allowed for increased the mesenteric lymph node trafficking of CX3CR1+ mononuclear phagocytes after antibiotic treatment.		[3]
Staphylococcus aureus (firmicutes)		MIC01208
Description	Many CX3CR1+ macrophages can captured significant numbers of Staphylococcus aureus.		[4]

References
1	Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense.Immunol Cell Biol. 2013 Mar;91(3):232-9. doi: 10.1038/icb.2012.79. Epub 2013 Feb 12.
2	CX(3)CR1(+) Macrophages and CD8(+) T Cells Control Intestinal IgA Production.J Immunol. 2018 Aug 15;201(4):1287-1294. doi: 10.4049/jimmunol.1701459. Epub 2018 Jul 9.
3	Critical Role for the Microbiota in CX(3)CR1(+) Intestinal Mononuclear Phagocyte Regulation of Intestinal TCell Responses.Immunity. 2018 Jul 17;49(1):151-163.e5. doi: 10.1016/j.immuni.2018.05.009. Epub 2018 Jul 3.
4	Perivascular localization of macrophages in the intestinal mucosa is regulated by Nr4a1 and the microbiome.Nat Commun. 2020 Mar 12;11(1):1329. doi: 10.1038/s41467-020-15068-4.

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