Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0084)
HIF Name
Defensin beta 120
HIF Synonym(s)
Defb120, DEFB120, DEFB-19, DEFB-20, ESC42-RELA
HIF Classification
Antimicrobial peptide (AMP)
Molecular Function
Antibiotic; Antimicrobial; Defensin
Description DEFB120 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system. [1]
Pfam Beta defensin (PF13841 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
DB119_HUMAN
APD ID
AP01474
Microbe Species (MIC) Regulated by This HIF
         Candida albicans (budding yeasts) MIC00317
             Description The DEFB120 peptide possessed potent killing with LD90 of 6080 g/ml against Escherichia coli and Candida albicans, although higher concentrations were required with LD90 of 80100 g/ml against Staphylococcus aureus. [2]
         Escherichia coli (enterobacteria) MIC00516
             Description The DEFB120 peptide possessed potent killing with LD90 of 60g/ml against Escherichia coli and Candida albicans. [2]
         Staphylococcus aureus (firmicutes) MIC01208
             Description The DEFB120 peptide possessed potent killing with LD90 of 6080 g/ml against Escherichia coli and Candida albicans, although higher concentrations were required with LD90 of 80100 g/ml against Staphylococcus aureus. [2]
References
1 APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2 Production and characterization of recombinant human beta-defensin DEFB120.J Pept Sci. 2014 Apr;20(4):251-7. doi: 10.1002/psc.2611. Epub 2014 Jan 21.

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