Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0099)
HIF Name
Low affinity immunoglobulin gamma Fc region receptor II-a
HIF Synonym(s)
Fc fragment of IgG receptor IIa, FCGR2A, CD32, FCG2, FcGR, CDw32, FCGR2, IGFR2, FCGR2A1
HIF Classification
Fc Receptor (FCR)
Molecular Function
IgG-binding protein; Receptor
Description FcgRIIa also known as CD32a, is a subtype of Fc Receptor. [1]
Pfam Immunoglobulin domain (PF13895 )
Pathway Fc gamma R-mediated phagocytosis (hsa04666 )
Leishmaniasis (hsa05140 )
Osteoclast differentiation (hsa04380 )
Pathogenic Escherichia coli infection (hsa05130 )
Phagosome (hsa04145 )
Platelet activation (hsa04611 )
Staphylococcus aureus infection (hsa05150 )
Systemic lupus erythematosus (hsa05322 )
Tuberculosis (hsa05152 )
Yersinia infection (hsa05135 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
FCG2A_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Citrobacter rodentium (enterobacteria) MIC00366
             Description Indeed, in mice, IgG and activating FcgRs are protective against the systemic spread of Citrobacter rodentium, an enteropathic bacteria. [2]
         Mycobacteroides abscessus (actinobacteria) MIC00845
             Description The FcgRIIA-R131 polymorphism increases susceptibility to a number of infections and that IgG and FcgRs promote defense against Mycobacterial infection. [2]
References
1 A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer.J Hematol Oncol. 2013 Jan 4;6:1. doi: 10.1186/1756-8722-6-1.
2 Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis. Immunity. 2019 Apr 16;50(4):1099-1114.e10. doi: 10.1016/j.immuni.2019.02.006. Epub 2019 Mar 12.

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