Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0102)
HIF Name
Low affinity immunoglobulin gamma Fc region receptor III
HIF Synonym(s)
Fc fragment of IgG receptor IIIa, FCGR3A, FCG3, CD16A, FCGR3, IGFR3, IMD20, FCR-10, FCRIII, FCGRIII, FCRIIIA
HIF Classification
Fc Receptor (FCR)
Molecular Function
IgG-binding protein; Receptor
Description FcgR3 also known as CD16, is a subtype of Fc Receptor. [1]
Pfam Immunoglobulin domain (PF13895 )
Pathway Fc gamma R-mediated phagocytosis (hsa04666 )
Leishmaniasis (hsa05140 )
Natural killer cell mediated cytotoxicity (hsa04650 )
Osteoclast differentiation (hsa04380 )
Phagosome (hsa04145 )
Staphylococcus aureus infection (hsa05150 )
Systemic lupus erythematosus (hsa05322 )
Tuberculosis (hsa05152 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
FCG3A_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Akkermansia muciniphila (verrucomicrobia) MIC00056
             Description Akkermansia muciniphila decreased the proportion of CD16+ macrophages in the spleen. [2]
         Bacteroidetes (CFB bacteria) MIC00141
             Description The increased Bacteroidetes was negatively correlated with the variation of CD16+ monocyte percentage. [3]
         Citrobacter rodentium (enterobacteria) MIC00366
             Description Indeed, in mice, IgG and activating FcgRs are protective against the systemic spread of Citrobacter rodentium, an enteropathic bacteria. [4]
References
1 A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer.J Hematol Oncol. 2013 Jan 4;6:1. doi: 10.1186/1756-8722-6-1.
2 A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8(+) T cells in mice. Gut. 2020 Mar 13:gutjnl-2019-320105. doi: 10.1136/gutjnl-2019-320105. Online ahead of print.
3 Change in gut microbiota is correlated with alterations in the surface molecule expression of monocytes after Roux-en-Y gastric bypass surgery in obese type 2 diabetic patients. Am J Transl Res. 2017 Mar 15;9(3):1243-1254. eCollection 2017.
4 Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis. Immunity. 2019 Apr 16;50(4):1099-1114.e10. doi: 10.1016/j.immuni.2019.02.006. Epub 2019 Mar 12.

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