Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0125)
HIF Name
ICOS ligand
HIF Synonym(s)
B7H2, B7RP-1, B7RP1, CD275, ICOSLG, ICOSL, KIAA0653, ICOSLG
HIF Classification
Checkpoint molecule (CM)
Description ICOSLG is expressed on T cells to regulate responses to self-proteins. [1]
Pfam Immunoglobulin V-set domain (PF07686 )
Pathway Cell adhesion molecules (CAMs) (hsa04514 )
Intestinal immune network for IgA production (hsa04672 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
ICOSL_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Clostridia (firmicutes) MIC01851
             Description The strain-specific Clostridia colonization induced key anti-inflammatory molecules (IL-10 and ICOS) in Treg cells, leading to an attenuated phenotype in an allergic disease model. [2]
         Escherichia coli (enterobacteria) MIC00516
             Description Escherichia coli stimulation resulted in an increased percentage of CD11c-positive cells expressing B7RP-1 (ICOSLG). [3]
         Lactobacillus casei (firmicutes) MIC00707
             Description The expression of B7RP-1 (ICOSLG) was augmented after low-dose probiotic or Lactobacillus casei treatment. [3]
References
1 Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy.Clin Cancer Res. 2013 Sep 15;19(18):4917-24. doi: 10.1158/1078-0432.CCR-12-1972. Epub 2013 Jul 18.
2 The gut microbiome in food allergy.Ann Allergy Asthma Immunol. 2019 Mar;122(3):276-282. doi: 10.1016/j.anai.2018.12.012. Epub 2018 Dec 20.
3 Bacterial probiotic modulation of dendritic cells.Infect Immun. 2004 Jun;72(6):3299-309. doi: 10.1128/IAI.72.6.3299-3309.2004.

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