General Information of HIF (ID: HIFM0133)
HIF Name	Interferon-15
HIF Synonym(s)	interleukin 15, IL15
HIF Classification	Cytokine (Cyt)
Molecular Function	Cytokine
Description	IL-15. A cytokine released by epithelial cells in the kidney, skeletal muscle, liver, lungs, heart, and bone marrow, which stimulates production of T cells, esp.				[1]
Pfam	Interleukin 15 (PF02372 )
Pathway	Cytokine-cytokine receptor interaction (hsa04060 )
	Human T-cell leukemia virus 1 infection (hsa05166 )
	Intestinal immune network for IgA production (hsa04672 )
	JAK-STAT signaling pathway (hsa04630 )
	Pathways in cancer (hsa05200 )
	Rheumatoid arthritis (hsa05323 )
	TNF signaling pathway (hsa04668 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	IL15_HUMAN

Microbe Species (MIC) Regulated by This HIF
Ruminococcus bromii (firmicutes)			MIC01133
Description	Ruminococcus bromii induce a significant reduction in the pro-inflammatory cytokine interleukin-15.				[2]
Ruminococcus callidus (firmicutes)			MIC01134
Description	Ruminococcus callidus induce a significant reduction in the pro-inflammatory cytokine interleukin-15.				[2]

References
1	Immunobiology of the IL-15/IL-15R complex as an antitumor and antiviral agent.Cytokine Growth Factor Rev. 2017 Dec;38:10-21. doi: 10.1016/j.cytogfr.2017.08.002. Epub 2017 Sep 1.
2	Effect of Lactobacillus paracasei CNCM I-1572 on symptoms, gut microbiota, short chain fatty acids, and immune activation in patients with irritable bowel syndrome: A pilot randomized clinical trial. United European Gastroenterol J. 2018 May;6(4):604-613. doi: 10.1177/2050640617736478. Epub 2017 Oct 8.

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