Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0203)
HIF Name
Nuclear receptor ROR-alpha
HIF Synonym(s)
RAR related orphan receptor A, IDDECA, NR1F1, ROR1, ROR2, ROR3, RZR-ALPHA, RZRA
HIF Classification
Retinoic acid receptor (RAR)
Molecular Function
Activator; Developmental protein; DNA-binding; Receptor
Description Retinoic acid receptor-related orphan receptor (ROR) is a transcription factor required for the development of ILC2. [1]
Pfam Ligand-binding domain of nuclear hormone receptor (PF00104 )
Zinc finger, C4 type (two domains) (PF00105 )
Pathway Circadian rhythm (hsa04710 )
Inflammatory bowel disease (IBD) (hsa05321 )
Spinocerebellar ataxia (hsa05017 )
Th17 cell differentiation (hsa04659 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
RORA_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Enterococcus faecalis (firmicutes) MIC00548
             Description The antibacterial resistance of burned mice to Enterococcus faecalis oral infection was completely improved after treatment with SR3335, a specific inverse agonist of RORA. [1]
         Mycobacterium avium (actinobacteria) MIC00846
             Description RORA was also implicated in inflammatory disease caused by infection with the intracellular bacterium Mycobacterium avium subspecies paratuberculosis. [2]
         Salmonella sp. (enterobacteria) MIC01149
             Description The Rora is dispensable for Salmonella clearance. [3]
References
1 Lamina propria group 2 innate lymphoid cells impair the antibacterial defense of burned mice to enterococcal translocation.J Leukoc Biol. 2017 Dec;102(6):1451-1460. doi: 10.1189/jlb.4A0517-195R. Epub 2017 Sep 26.
2 Variations in T cell transcription factor gene structure and expression associated with the two disease forms of sheep paratuberculosis. Vet Res. 2016 Aug 17;47(1):83. doi: 10.1186/s13567-016-0368-3.
3 The orphan nuclear receptor ROR and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn's disease. Sci Immunol. 2016 Sep 2;1(3):eaaf8864. doi: 10.1126/sciimmunol.aaf8864. Epub 2016 Sep 2.

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