Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0205)
HIF Name
Nuclear receptor ROR-gamma
HIF Synonym(s)
RAR related orphan receptor C, IMD42, NR1F3, RORG, RZR-GAMMA, RZRG, TOR
HIF Classification
Retinoic acid receptor (RAR)
Molecular Function
Activator; Developmental protein; DNA-binding; Receptor
Description Nuclear receptor ROR-gamma(RORC) is a retinoic acid receptor-related orphan receptor,and is involved in many physiological processes, including regulation of metabolism, development and immunity as well as the circadian rhythm. [1]
Pfam Ligand-binding domain of nuclear hormone receptor (PF00104 )
Zinc finger, C4 type (two domains) (PF00105 )
Pathway Circadian rhythm (hsa04710 )
Inflammatory bowel disease (IBD) (hsa05321 )
Th17 cell differentiation (hsa04659 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
RORG_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Escherichia coli (enterobacteria) MIC00516
             Description RORC expression was associated with Escherichia coli. [2]
         Lactobacillus reuteri (firmicutes) MIC00731
             Description Subjects received supplementation with Lactobacillus reuteri, the FOXP3 concentration increased significantly, resulting in decreased a RoR/FOXP3 mRNA ratio. [2]
         Staphylococcus aureus (firmicutes) MIC01208
             Description The ROR- mRNA levels were higher after Staphylococcus aureus infection. [3]
References
1 REV-ERB and ROR nuclear receptors as drug targets.Nat Rev Drug Discov. 2014 Mar;13(3):197-216. doi: 10.1038/nrd4100.
2 Crying Time and ROR/FOXP3 Expression in Lactobacillus reuteri DSM17938-Treated Infants with Colic: A Randomized Trial. J Pediatr. 2018 Jan;192:171-177.e1. doi: 10.1016/j.jpeds.2017.08.062. Epub 2017 Sep 29.
3 Cloxacillin control of experimental arthritis induced by SEC(+) Staphylococcus aureus is associated with downmodulation of local and systemic cytokines. Cell Microbiol. 2016 Jul;18(7):998-1008. doi: 10.1111/cmi.12563. Epub 2016 Feb 1.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.