General Information of HIF (ID: HIFM0215)
HIF Name	Substance P
HIF Synonym(s)	Substance P, SP
HIF Classification	Antimicrobial peptide (AMP)
Molecular Function	Neuropeptide; Neurotransmitter
Description	Substance P has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.				[1]
Pathway	Neuroactive ligand-receptor interaction (hsa04080 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	TKN1_HUMAN
	APD ID	AP01470

Microbe Species (MIC) Regulated by This HIF
Bacillus cereus (firmicutes)			MIC00122
Description	Substance P is without effect on the growth of gram-positive Bacillus cereus.				[2]
Pseudomonas fluorescens (gamma-proteobacteria)			MIC01056
Description	Substance P is without effect on the growth of gram-negative Pseudomonas fluorescens bacteria.				[2]
Staphylococcus aureus (firmicutes)			MIC01208
Description	Substance P is without effect on the growth of gram-positive Staphylococcus aureus bacteria.				[2]
Staphylococcus epidermidis (firmicutes)			MIC01214
Description	Substance P is without effect on the growth of gram-positive Staphylococcus epidermidis.				[2]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	Substance P and Calcitonin Gene-Related Peptide: Key Regulators of Cutaneous Microbiota Homeostasis.Front Endocrinol (Lausanne). 2017 Jan 30;8:15. doi: 10.3389/fendo.2017.00015. eCollection 2017.

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