General Information of HIF (ID: HIFM0274)
HIF Name	Immunoglobulin Y
HIF Synonym(s)	IgY
HIF Classification	Immunoglobulin (Ig)
Description	Immunoglobulin Y(IgY) is a class of proteins which are formed by the immune system in reaction to certain foreign substances, and specifically recognize them.				[1]

Microbe Species (MIC) Regulated by This HIF
Solobacterium moorei (firmicutes)			MIC01192
Description	the specific IgY could decrease the bacterial level after infection with Solobacterium moorei.				[2]
Yersinia pseudotuberculosis (enterobacteria)			MIC01402
Description	Our data suggest that IMs differentiate into DCs in MLN pyogranulomas and direct adaptive responses in T cells at the expense of innateimmunity during oral Y.pseudotuberculosis infection.				[3]

References
1	Features of chicken egg yolk immunoglobulin (IgY) against the infection of red-spotted grouper nervous necrosis virus.Fish Shellfish Immunol. 2018 Sep;80:534-539. doi: 10.1016/j.fsi.2018.06.024. Epub 2018 Jun 12.
2	Chicken egg yolk antibody (IgY) controls Solobacterium moorei under in vitro and in vivo conditions. Appl Biochem Biotechnol. 2012 Nov;168(6):1448-58. doi: 10.1007/s12010-012-9869-3. Epub 2012 Sep 12.
3	CCR2(+) Inflammatory Monocytes Are Recruited to Yersinia pseudotuberculosis Pyogranulomas and Dictate Adaptive Responses at the Expense of Innate Immunity during Oral Infection. Infect Immun. 2018 Feb 20;86(3):e00782-17. doi: 10.1128/IAI.00782-17. Print 2018 Mar.

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