Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00435)
MIC Name Collinsella stercoris (actinobacteria)
MIC Synonyms Collinsella group 1
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Coriobacteriia
Order: Coriobacteriales
Family: Coriobacteriaceae
Genus: Collinsella
Species: Collinsella stercoris
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Positive
Host Relationship Commensal
Genome Size (bp) 2399821
Description Collinsella stercoris is an obligately anaerobic, Gram positive bacterium. The species is associated with chronic kidney disease.
External Links Taxonomy ID
147206
Genome Assembly ID
ASM15621v1
GOLD Organism ID
Go0276072
Disease Relevance
          Chronic kidney disease  [ICD-11: GB61]
             Description Collinsella stercoris was superior in discriminating CKD(Chronic kidney disease) from the controls than the use of urine protein/creatinine ratio, even at early-stage of disease. [1]
Host Genetic Factors (HGFs)
          AMY1A
             HGF ID HGF2311 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description Gut microbiome Coriobacteriaceae differs between high AMY1-CN and low AMY1-CN groups at the OTU Level (p-value<0.05). [2]
          C4B
             HGF ID HGF2348 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description The low C4B-CN has been significantly associated with the abundance of Collinsella (p-value<0.05). [3]
Environmental Factor(s)
             Disbiome ID
      185
             gutMDisorder ID
      gm0217
References
1 Gut Microbiota as Diagnostic Tools for Mirroring Disease Progression and Circulating Nephrotoxin Levels in Chronic Kidney Disease: Discovery and Validation Study. Int J Biol Sci. 2020 Jan 1;16(3):420-434. doi: 10.7150/ijbs.37421. eCollection 2020.
2 Human Salivary Amylase Gene Copy Number Impacts Oral and Gut Microbiomes.Cell Host Microbe. 2019 Apr 10;25(4):553-564.e7. doi: 10.1016/j.chom.2019.03.001.
3 C4B gene influences intestinal microbiota through complement activation in patients with paediatric-onset inflammatory bowel disease.Clin Exp Immunol. 2017 Dec;190(3):394-405. doi: 10.1111/cei.13040. Epub 2017 Sep 25.

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