Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00983)
MIC Name Phascolarctobacterium faecium (firmicutes)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Negativicutes
Order: Acidaminococcales
Family: Acidaminococcaceae
Genus: Phascolarctobacterium
Species: Phascolarctobacterium faecium
Oxygen Sensitivity Anaerobe
Microbial Metabolism Fermentative
Gram Negative
Description Phascolarctobacterium faecium is an anaerobic microbe known as a member of the human gut microbiome.
External Links Taxonomy ID
33025
Genome Assembly ID
ASM971903v1
GOLD Organism ID
Go0234426
Disease Relevance
          Autoimmune liver disease  [ICD-11: DB96]
             Description A low abundance of genus Phascolarctobacterium positively correlated with the presence of IBD, both PSC-IBD and UC. [1]
          Ulcerative colitis  [ICD-11: DD71]
             Description A low abundance of genus Phascolarctobacterium positively correlated with the presence of ulcerative colitis. [1]
Host Genetic Factors (HGFs)
          AMY1A
             HGF ID HGF2311 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description Oral microbiome Veillonellaceae differs between high AMY1-CN and low AMY1-CN groups at the OTU level (p-value<0.05). [2]
          rs7943358
             HGF ID HGF1648 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7943358 SNP is significantly associated with the abundance of Phascolarctobacterium (p-value=2.61E-05). [3]
          rs2541522
             HGF ID HGF1294 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2541522 SNP is significantly associated with the abundance of Phascolarctobacterium (p-value=4.58E-06). [3]
          rs2141673
             HGF ID HGF1600 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2141673 SNP is significantly associated with the abundance of Phascolarctobacterium (p-value=3.05E-05). [3]
          rs1471759
             HGF ID HGF1599 HGF Info       Class Single Nucleotide Polymorphism: Non coding transcript variant (SNP-NCTV)
             Description The rs1471759 SNP is significantly associated with the abundance of Phascolarctobacterium (p-value=2.61E-05). [3]
          rs1466553
             HGF ID HGF1601 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1466553 SNP is significantly associated with the abundance of Phascolarctobacterium (p-value=2.61E-05). [3]
          rs12367572
             HGF ID HGF1477 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs12367572 SNP is significantly associated with the abundance of Phascolarctobacterium (p-value=1.58E-06). [3]
          rs6074022
             HGF ID HGF2569 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs6074022 SNP is associated with the abundance of Phascolarctobacterium. [4]
          rs10486483
             HGF ID HGF2543 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs10486483 SNP is associated with the abundance of Phascolarctobacterium. [4]
          rs3742130
             HGF ID HGF2570 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-SV)
             Description The rs3742130 SNP is associated with the abundance of Phascolarctobacterium. [4]
          rs1569328
             HGF ID HGF2571 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs1569328 SNP is associated with the abundance of Phascolarctobacterium. [4]
          rs7097656
             HGF ID HGF2572 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7097656 SNP is associated with the abundance of Phascolarctobacterium. [4]
          rs12568930
             HGF ID HGF2533 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs12568930 SNP is associated with the abundance of Phascolarctobacterium. [4]
          rs4845604
             HGF ID HGF2573 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs4845604 SNP is associated with the abundance of Phascolarctobacterium. [4]
          rs12994997
             HGF ID HGF2541 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs12994997 SNP is associated with the abundance of Phascolarctobacterium. [4]
          rs2488389
             HGF ID HGF2574 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2488389 SNP is associated with the abundance of Phascolarctobacterium. [4]
          rs12103
             HGF ID HGF2575 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-SV)
             Description The rs12103 SNP is associated with the abundance of Phascolarctobacterium. [4]
          rs17119
             HGF ID HGF2576 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-UV)
             Description The rs17119 SNP is associated with the abundance of Phascolarctobacterium. [4]
Host Immune Factors (HIFs)
          C-X-C motif chemokine 11
             HIF ID HIFM0075 HIF Info       Class Cytokine (Cyt)
             Description At the genus level, Phascolarctobacterium is associated with the CXCL11 expression. [5]
          CD16+ Natural Killer cells
             HIF ID HIFC0094 HIF Info       Class Natural killer cells (NKCs)
             Description The increased proportion of CD16+ NK cells was associated with the decrease of gut commensal bacteria(Phascolarctobacterium). [6]
Environmental Factor(s)
             Disbiome ID
      181
             gutMDisorder ID
      gm0524
References
1 Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis. World J Gastroenterol. 2017 Jul 7;23(25):4548-4558. doi: 10.3748/wjg.v23.i25.4548.
2 Human Salivary Amylase Gene Copy Number Impacts Oral and Gut Microbiomes.Cell Host Microbe. 2019 Apr 10;25(4):553-564.e7. doi: 10.1016/j.chom.2019.03.001.
3 Genome-Wide Association Studies of the Human Gut Microbiota.PLoS One. 2015 Nov 3;10(11):e0140301. doi: 10.1371/journal.pone.0140301. eCollection 2015.
4 A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice. Genetics. 2020 Mar;214(3):719-733. doi: 10.1534/genetics.119.303013. Epub 2020 Jan 2.
5 Prebiotic supplementation in frail older people affects specific gut microbiota taxa but not global diversity. Microbiome. 2019 Mar 13;7(1):39. doi: 10.1186/s40168-019-0654-1.
6 Dysbiosis of gut microbiome affecting small intestine morphology and immune balance: a rhesus macaque model.Zool Res. 2020 Jan 18;41(1):20-31. doi: 10.24272/j.issn.2095-8137.2020.004.

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