Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00716)
MIC Name Lactobacillus gasseri (firmicutes)
Body Site Vagina
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus gasseri
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Respiratory or Fermentative
Gram Positive
Host Relationship Probiotic
Genome Size (bp) 1894360
No. of Coding Genes 1934
No. of Non-Coding Genes 52
No. of Small Non-Coding Genes 52
No. of Gene Transcripts 1986
No. of Base Pairs 1912752
Description Lactobacillus gasseri is an anaerobic, Gram-positive bacterium that falls into the category of lactic acid bacteria. It is also a rod shaped and of the non-spore-forming type.
External Links Taxonomy ID
1596
Genome Assembly ID
ASM154652v1
GOLD Organism ID
Go0505091
Disease Relevance
          Type 2 diabetes mellitus  [ICD-11: 5A11]
             Description Lactobacillus gasseri is upregulated in type 2 diabetes. [1]
Host Genetic Factors (HGFs)
          rs58391561
             HGF ID HGF1263 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs58391561 SNP was significantly associated with the abundance of Lactobacillus gasseri (p-value<1.00E-08). [2]
Host Immune Factors (HIFs)
          B cells
             HIF ID HIFC0001 HIF Info       Class B cells (BCs)
             Description B cells could produce more IgA in response to Lactobacillus gasseri SBT2055 infection. [3]
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description Lactobacillus gasseri infection could increase the production of IL-10. [4]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Lactobacillus gasseri could decrease the production of TNF-Alpha. [4]
Environmental Factor(s)
             Disbiome ID
      334
             gutMDisorder ID
      gm0399
References
1 Intestinal Lactobacillus in health and disease, a driver or just along for the ride. Curr Opin Biotechnol. 2018 Feb;49:140-147. doi: 10.1016/j.copbio.2017.08.004. Epub 2017 Sep 1.
2 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
3 Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation.J Immunol Res. 2019 Apr 16;2019:1603758. doi: 10.1155/2019/1603758. eCollection 2019.
4 Impact of Exopolysaccharides (EPSs) of Lactobacillus gasseri strains isolated from human vagina on cervical tumor cells (HeLa). Anaerobe. 2017 Oct;47:137-144. doi: 10.1016/j.anaerobe.2017.05.013. Epub 2017 May 26.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.