General Information of MIC (ID: MIC00999)
MIC Name	Porphyromonas endodontalis (CFB bacteria)
MIC Synonyms	Bacteroides endodontalis
Body Site	Oral Cavity
Lineage	Kingdom: Bacteria Phylum: Bacteroidetes Class: Bacteroidia Order: Bacteroidales Family: Porphyromonadaceae Genus: Porphyromonas Species: Porphyromonas endodontalis
Oxygen Sensitivity	Obligate anaerobe
Microbial Metabolism	Asaccharolytic
Gram	Negative
Genome Size (bp)	2064508
Description	Porphyromonas endodontalis is a species of obligate anaerobic, Gram negative black pigmented, nonsporeforming, nonmotile microbe associated with periodontitis, endodontic infections, gingivitis and tooth pulp necrosis.
External Links	Taxonomy ID	28124
	Genome Assembly ID	ASM17481v1
	GOLD Organism ID	Go0006078
Disease Relevance
Gingival disease  [ICD-11: DA0B]
Description	Porphyromonas gingivalis, Prevotella intermedia and Porphyromonas endodontalis had higher relative abundance in gingivitis.				[1]
Periodontal disease  [ICD-11: DA0C]
Description	There was a high prevalence of Porphyromonas endodontalis in periodontitis sites.				[2]
Skin abscesses  [ICD-11: 1B75]
Description	Porphyromonas endodontalis was associated with the presence of sinus tract and abscess formation.				[3]
Tooth pulp necrosis  [ICD-11: DA01]
Description	Porphyromonas endodontalis was associated with tooth pulp necrosis.				[4]

Host Genetic Factors (HGFs)
hsa-miR-146a-5p
HGF ID	HGF0252	HGF Info	Class	Non-coding RNA: Micro (ncRNA-miRNA)
Description	The miR-146a was significantly increased in MC3T3-E1 cells stimulated with Porphyromonas endodontalis LPS.				[5]

Host Immune Factors (HIFs)
Tumor necrosis factor
HIF ID	HIFM0226	HIF Info	Class	Cytokine (Cyt)
Description	Porphyromonas endodontalis total lipids were shown to promote TNF-Alpha secretion from RAW 264.7 cells.				[4]
Toll-like receptor 2
HIF ID	HIFM0217	HIF Info	Class	Toll-like receptor (TLR)
Description	The total lipid extract of Porphyromonas endodontalis mediates its inhibitory effects on osteoblasts through engagement of TLR2.				[4]

Environmental Factor(s)
Disbiome ID			680
gutMDisorder ID			gm0533

References
1	Subgingival Microbiome of Gingivitis in Chinese Undergraduates. Chin J Dent Res. 2017;20(3):145-152. doi: 10.3290/j.cjdr.a38769.
2	Porphyromonas endodontalis in chronic periodontitis: a clinical and microbiological cross-sectional study. J Oral Microbiol. 2012;4. doi: 10.3402/jom.v4i0.10123. Epub 2012 Jan 5.
3	Detection of Porphyromonas endodontalis, Porphyromonas gingivalis and Prevotella intermedia in primary endodontic infections in a Chinese population. Int Endod J. 2012 Aug;45(8):773-81. doi: 10.1111/j.1365-2591.2012.02035.x. Epub 2012 Mar 19.
4	Biologic activity of porphyromonas endodontalis complex lipids. J Endod. 2014 Sep;40(9):1342-8. doi: 10.1016/j.joen.2014.02.017. Epub 2014 Apr 13.
5	microRNA-146a and Hey2 form a mutual negative feedback loop to regulate the inflammatory response in chronic apical periodontitis. J Cell Biochem. 2019 Jan;120(1):645-657. doi: 10.1002/jcb.27422. Epub 2018 Aug 20.

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