| General Information of MIC (ID: MIC01993) |
| MIC Name |
Leishmania major (kinetoplastids)
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| MIC Synonyms |
Leishmania tropica major
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| Body Site |
Blood
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| Lineage |
Kingdom: Eukaryota
Phylum: Euglenozoa
Class: Kinetoplastea
Order: Trypanosomatida
Family: Trypanosomatidae
Genus: Leishmania
Species: Leishmania major
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| Oxygen Sensitivity |
Aerobe
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| Microbial Metabolism |
Respiratory
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| Host Relationship |
Pathogen
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| Description |
Leishmania major is a species of parasites found in the genus Leishmania, and is associated with the disease zoonotic cutaneous leishmaniasis.
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| External Links |
Taxonomy ID |
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| GOLD Organism ID |
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| Host Immune Factors (HIFs) |
| IgG plasma B cell |
| HIF ID |
HIFC0219 |
HIF Info
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Class |
B cells (BCs) |
| Description |
Leishmania stimulated B-cells to differentiate into short-lived IgG plasma cells with limited lifespan in the medullar cords of lymph nodes and splenic red pulp in the primary immune response. |
[1] |
| IgM plasma B cell |
| HIF ID |
HIFC0220 |
HIF Info
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Class |
B cells (BCs) |
| Description |
Leishmania stimulated B-cells to differentiate into short-lived IgM plasma cells with limited lifespan in the medullar cords of lymph nodes and splenic red pulp in the primary immune response. |
[1] |
| Monocytes |
| HIF ID |
HIFC0024 |
HIF Info
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Class |
Monocytes (Mono) |
| Description |
Recruitment of monocytes is essential for effective control and clearance of Leishmania major. |
[2] |
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| References |
| 1 |
Disruption of Splenic Lymphoid Tissue and Plasmacytosis in Canine Visceral Leishmaniasis: Changes in Homing and Survival of Plasma Cells.PLoS One. 2016 May 31;11(5):e0156733. doi: 10.1371/journal.pone.0156733. eCollection 2016.
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| 2 |
Monocyte recruitment during infection and inflammation.Nat Rev Immunol. 2011 Oct 10;11(11):762-74. doi: 10.1038/nri3070.
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