General Information of MIC (ID: MIC00046)
MIC Name	Aeromonas hydrophila (gamma-proteobacteria)
MIC Synonyms	Bacillus hydrophilus
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Aeromonadales Family: Aeromonadaceae Genus: Aeromonas Species: Aeromonas hydrophila
Oxygen Sensitivity	Facultative anaerobe
Microbial Metabolism	Saccharolytic; Fermentative; hydrogen used as energy source
Gram	negative
Genome Size (bp)	5088929
No. of Coding Genes	4361
No. of Non-Coding Genes	153
No. of Small Non-Coding Genes	153
No. of Gene Transcripts	4514
No. of Base Pairs	5088929
Description	Aeromonas hydrophila is a rod-shaped, facultative anaerobic, saccharolytic, fermentative, Gram-negative bacterium. A. hydrophila is an opportunistic pathogen in humans causing extraintestinal and intestinal infections
External Links	Taxonomy ID	644
	Genome Assembly ID	ASM72496v1
	GOLD Organism ID	Go0074685

Host Genetic Factors (HGFs)
hsa-miR-429b
HGF ID	HGF0678	HGF Info	Class	Non-coding RNA: Micro (ncRNA-miRNA)
Description	An inverse correlation in the expression of miR-429b and CiGadd45g in CIK cells after Aeromonas hydrophila challenge.				[1]

Host Immune Factors (HIFs)
Interleukin-1 beta
HIF ID	HIFM0138	HIF Info	Class	Cytokine (Cyt)
Description	The transcriptional levels of immune related genes such as IL-1beta could against Aeromonas hydrophila infection.				[2]
Tumor necrosis factor
HIF ID	HIFM0226	HIF Info	Class	Cytokine (Cyt)
Description	The transcriptional levels of TLR2 (Toll like receptor 2), myeloid differentiation factor 88 (MyD88), Toll/IL-1 receptor domain-containing adaptor protein (TIRAP), interleukin-1Beta (IL-1Beta) and tumor necrosis factor-Alpha1 (TNF-Alpha1) in spleen and kidney significantly increased post the Aeromonas hydrophila challenge compared to the pre challenge.				[2]
Immunoglobulin D
HIF ID	HIFM0277	HIF Info	Class	Immunoglobulin (Ig)
Description	In bacterial (Aeromonas hydrophila) infection, transcripts of Labeo rohita IgD increased more dramatically in liver followed by kidney and gill.				[3]
Toll like receptor 2 signalling pathway
HIF ID	HIFP0044	HIF Info	Class	Signaling pathway (SP)
Description	The transcriptional levels of TLR2 (Toll like receptor 2), myeloid differentiation factor 88 (MyD88), Toll/IL-1 receptor domain-containing adaptor protein (TIRAP), interleukin-1Beta (IL-1Beta) and tumor necrosis factor-Alpha1 (TNF-Alpha1) in spleen and kidney significantly increased post the Aeromonas hydrophila challenge compared to the pre challenge.				[2]
Toll-like receptor 2
HIF ID	HIFM0217	HIF Info	Class	Toll-like receptor (TLR)
Description	The transcriptional levels of immune related genes such as TLR2 could against Aeromonas hydrophila infection.				[2]

Environmental Factor(s)
Disbiome ID			102
gutMDisorder ID			gm0027
aBiofilm Organism			Aeromonas hydrophila

References
1	Cloning, functional analysis, and microRNA-induced negative regulation of growth arrest and DNA damage-inducible 45 (Gadd45g) in grass carp (Ctenopharyngodon idella). Dev Comp Immunol. 2019 Oct;99:103400. doi: 10.1016/j.dci.2019.103400. Epub 2019 May 23.
2	Replacement of fishmeal by spirulina Arthrospira platensis affects growth, immune related-gene expression in gibel carp (Carassius auratus gibelio var. CAS III), and its challenge against Aeromonas hydrophila infection. Fish Shellfish Immunol. 2018 Aug;79:265-273. doi: 10.1016/j.fsi.2018.05.022. Epub 2018 May 26.
3	Immunoglobulin (Ig) D in Labeo rohita is widely expressed and differentially modulated in viral, bacterial and parasitic antigenic challenges.Vet Immunol Immunopathol. 2016 Oct 15;179:77-84. doi: 10.1016/j.vetimm.2016.08.008. Epub 2016 Aug 9.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.